At NIMH he contributed to early studies which examined pairs of twins to determine the connection between development of schizophrenia and obstetrical complications and various other neurological abnormalities. At NIDA he was one of the key researchers who changed the medical view of tobacco smoking from an unhealthy habit to a diagnosable drug addiction—after which cigarette makers nicknamed him "Doctor Death" to the tobacco industry. Dr. Pollin emphasized supporting family-oriented drug prevention programs and during this time the rate of cannabis abuse in high school children declined.